Which method of drug administration is likely to produce an intense high and increase addiction potential?

The method of drug administration that is likely to produce an intense high and increase addiction potential is smoking or injecting. This stems from the rapid onset of effects that these methods provide. When substances are smoked or injected, they enter the bloodstream almost immediately, leading to an intense and immediate high that users often find more rewarding compared to other methods.

The quick delivery to the brain enhances the euphoric effects of the drug, which can reinforce behavior and increase the likelihood of continued use, raising the risk of addiction. With quicker onset and higher intensity of effects, individuals may be more inclined to repeat the behavior, leading to a stronger psychological dependence.

In contrast, methods like oral ingestion often result in a slower absorption and delayed effects, which can diminish the intensity of the high. Transdermal patches also deliver a more gradual dose over time rather than an immediate spike in drug levels, and inhaling vapors, while it can also produce a rapid effect, generally doesn't reach the same addictive potential as smoking or injecting. Thus, for those seeking immediate and powerful effects, the methods of smoking or injecting drugs significantly raise the risk of addiction.